• DRAMP ID

    • DRAMP03964
    • Peptide Name

    • Cecropin A(1-8)-Magainin 2(1-12)hybrid peptide analogue (P2)
    • Source

    • Synthetic construct
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • KWKLFKKIPKFLHSAKKF
    • Sequence Length

    • 18
    • Protein Existence

    • Synthetic
    • Biological Activity

    • Antimicrobial, Antibacterial
    • Target Organism

    • No MICs found in DRAMP database
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Alpha helix
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP03964 helical wheel diagram
  • 1F0E-> 
    • Predicted Structure

    • There is no predicted structure for DRAMP03964.
    • Formula

    • C115H180N28O20
    • Absent Amino Acids

    • CDEGMNQRTVY
    • Common Amino Acids

    • K
    • Mass

    • 2274.87
    • PI

    • 10.78
    • Basic Residues

    • 8
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 8
    • Net Charge

    • +8
    • Boman Index

    • -19.07
    • Hydrophobicity

    • -0.639
    • Aliphatic Index

    • 70.56
    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 5500
    • Absorbance 280nm

    • 323.53
    • Polar Residues

    • 1

DRAMP03964

DRAMP03964 chydropathy plot
    • P2 retained effective lytic activities and pore-forming activity.

  • ·Literature 1
    • Title

    • Role of the hinge region and the tryptophan residue in the synthetic antimicrobial peptides, cecropin A(1-8)-magainin 2(1-12) and its analogues, on their antibiotic activities and structures.
    • Reference

    • Biochemistry. 2000 Oct 3;39(39):11855-11864.
    • Author

    • Oh D, Shin SY, Lee S, Kang JH, Kim SD, Ryu PD, Hahm KS, Kim Y.