General Information
-
DRAMP ID
- DRAMP03983
-
Peptide Name
- C-6 (analog of P18)
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Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
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Sequence
- KWKLFKKIPKFLHLA
-
Sequence Length
- 15
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UniProt Entry
- No entry found
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Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antitumor
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Target Organism
-
- Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=6.25-12.5 µM), Pseudomonas aeruginosa KCTC 1637 (MIC=6.25 µM), Proteus vulgaris (MIC=3.125 µM).
- Gram-positive bacteria: Bacillus subtilis KCTC 1918 (MIC=0.78 µM), Staphylococcus aureus KCTC 1621 (MIC=6.25 µM), Bacillus megaterium KCTC 1096 (MIC=3.125 µM).
- Tumor cells: MDA-MB-361 (IC50=47.0 µM), Jurkat (IC50=21.0 µM), K-562 (IC50=27.0 µM), Normal cells NIH 3T3 (IC50=100.0 µM).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP03983.
Physicochemical Information
-
Formula
- C97H153N23O16
Absent Amino Acids
- CDEGMNQRSTVY
Common Amino Acids
- K
Mass
- 1897.43
PI
- 10.6
Basic Residues
- 6
Acidic Residues
- 0
Hydrophobic Residues
- 8
Net Charge
- +6
-
Boman Index
- -2.63
Hydrophobicity
- -0.127
Aliphatic Index
- 110.67
Half Life
-
- Mammalian:1.3 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 392.86
Polar Residues
- 0
DRAMP03983
Comments Information
Function
- Has antibacterial activiy against Gram-negative and Gram-positive bacteria. Also has antitumor activity.
Literature Information
- ·Literature 1
-
Title
- Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs.
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Pubmed ID
- 12005420
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Reference
- J Pept Res. 2001 Dec;58(6):504-514.
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Author
- Shin SY, Lee SH, Yang ST, Park EJ, Lee DG, Lee MK, Eom SH, Song WK, Kim Y, Hahm KS, Kim JI.