General Information
-
DRAMP ID
- DRAMP03988
-
Peptide Name
- L3K3W4 (LlKmWn model peptide)
-
Source
- Synthetic construct (De novo design)
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- LLKWLKK
-
Sequence Length
- 7
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+
-
Target Organism
-
- Gram-positive bacterium: Micrococcus luteus ATCC 10240 (MIC=25 µg/ml).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP03988.
Physicochemical Information
-
Formula
- C47H81N11O8
Absent Amino Acids
- ACDEFGHIMNPQRSTVY
Common Amino Acids
- KL
Mass
- 928.23
PI
- 10.3
Basic Residues
- 3
Acidic Residues
- 0
Hydrophobic Residues
- 4
Net Charge
- +3
-
Boman Index
- 0.44
Hydrophobicity
- -0.171
Aliphatic Index
- 167.14
Half Life
-
- Mammalian:5.5 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 916.67
Polar Residues
- 0
DRAMP03988
Comments Information
Function
- Has antibacterial activiy against Gram-positive bacteria.
Literature Information
- ·Literature 1
-
Title
- De novo generation of antimicrobial LK peptides with a single tryptophan at the critical amphipathic interface.
-
Pubmed ID
- 19544481
-
Reference
- J Pept Sci. 2009 Sep;15(9):583-588.
-
Author
- Kang SJ, Won HS, Choi WS, Lee BJ.