• • DRAMP ID

  • DRAMP03993

• • Peptide Name

  • L5K5W6 (LlKmWn model peptide)

• • Source

  • Synthetic construct (De novo design)

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • KKLLKWLKKLL

• • Sequence Length

  • 11

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • Gram-positive bacteria: Bacillus subtilis ATCC 6633 (MIC=6.3 µg/ml), Staphylococcus aureus ATCC 6538p (MIC=6.3 µg/ml), Staphylococcus epidermis ATCC 12228 (MIC=6.3 µg/ml), Micrococcus luteus ATCC 10240 (MIC=6.3 µg/ml);
    • Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=12.5 µg/ml), Shigella dysentariae ATCC 9752 (MIC=6.3 µg/ml), Salmonella typhomurium ATCC 14028 (MIC=25 µg/ml), Klebsiella pneumoniae ATCC 10031 (MIC=6.3 µg/ml), Pseudomonas aeruginosa ATCC 27 853 (MIC=25 µg/ml).

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Alpha helix

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• Please click DRAMP03993_predicted_structure.pdb to download.

DRAMP03993

• • Function

  • Has antibacterial activiy against Gram-negative and Gram-positive bacteria.

• ·Literature 1

• • Title

  • De novo generation of antimicrobial LK peptides with a single tryptophan at the critical amphipathic interface.

• • Pubmed ID

  • 19544481

• • Reference

  • J Pept Sci. 2009 Sep;15(9):583-588.

• • Author

  • Kang SJ, Won HS, Choi WS, Lee BJ.