General Information
-
DRAMP ID
- DRAMP03996
-
Peptide Name
- L7K5W7 (LlKmWn model peptide)
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Source
- Synthetic construct (De novo design)
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Family
- Not found
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Gene
- Not found
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Sequence
- LKKLLKWLLKLLK
-
Sequence Length
- 13
-
UniProt Entry
- No entry found
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Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+
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Target Organism
-
- Gram-positive bacteria: Bacillus subtilis ATCC 6633 (MIC=3.1 µg/ml), Staphylococcus aureus ATCC 6538p (MIC=12.5 µg/ml), Staphylococcus epidermis ATCC 12228 (MIC=12.5 µg/ml), Micrococcus luteus ATCC 10240 (MIC=3.1 µg/ml).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP03996.
Physicochemical Information
-
Formula
- C83H149N19O14
Absent Amino Acids
- ACDEFGHIMNPQRSTVY
Common Amino Acids
- L
Mass
- 1637.21
PI
- 10.6
Basic Residues
- 5
Acidic Residues
- 0
Hydrophobic Residues
- 8
Net Charge
- +5
-
Boman Index
- 9.02
Hydrophobicity
- 0.477
Aliphatic Index
- 210
Half Life
-
- Mammalian:5.5 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 458.33
Polar Residues
- 0
DRAMP03996
Comments Information
Function
- Has antibacterial activiy against Gram-positive bacteria.
Literature Information
- ·Literature 1
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Title
- De novo generation of antimicrobial LK peptides with a single tryptophan at the critical amphipathic interface.
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Pubmed ID
- 19544481
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Reference
- J Pept Sci. 2009 Sep;15(9):583-588.
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Author
- Kang SJ, Won HS, Choi WS, Lee BJ.