• • DRAMP ID

  • DRAMP03999

• • Peptide Name

  • [A6]-IsCT (Mutant: W6A; IsCT analog)

• • Source

  • Synthetic construct

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • ILGKIAEGIKSLF

• • Sequence Length

  • 13

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • [Ref.15369808]Gram-negative bacteria: Escherichia coli KCTC 1682 (MIC=64 µM), Pseudomonas aeruginosa KCTC 1637 (MIC=32 µM), Salmonella typhimurium KCTC 1926 (MIC>64 µM);
    • Gram-positive bacteria: Staphylococcus epidermidis KCTC 1917 (MIC>64 µM), Staphylococcus aureus KCTC 1621 (MIC>64 µM).

• • Hemolytic Activity

  • • [Ref.15369808]Non-hemolytic activity

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Cell membrane

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• Please click DRAMP03999_predicted_structure.pdb to download.

DRAMP03999

• • Function

  • [A6]-IsCT did not cause any hemolysis at peptide concentrations as high as 100 µM, indicating that Trp6 is important for both the hemolytic activity and antibacterial activity of IsCT.

• • Chemical modification

  • C-terminal amidation.

• ·Literature 1

• • Title

  • Antibiotic activity and structural analysis of the scorpion-derived antimicrobial peptide IsCT and its analogs.

• • Pubmed ID

  • 15369808

• • Reference

  • Biochem Biophys Res Commun. 2004 Oct 15;323(2):712-719.

• • Author

  • Lee K, Shin SY, Kim K, Lim SS, Hahm KS, Kim Y.