• • DRAMP ID

  • DRAMP04004

• • Peptide Name

  • Gramicidin analogue ([Scr2]-GS)

• • Source

  • Synthetic construct

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • VSLFPVXLFP

• • Sequence Length

  • 10

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • Gram-positive bacteria: Staphylococcus aureus ATCC 6538 P(MIC=25 µg/ml), Streptococcus pyogenes N.Y.5 (MIC=25 µg/ml), Myotis flavus ATCC 10240 (MIC=3.1 µg/ml), Bacillus subtilis ATCC 6633 (MIC=6.3 µg/ml);
    • Gram-negative bacteria: Corynebacterium diphtheriae P.W.8 (MIC=3.1 µg/ml).

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP04004.

DRAMP04004

• • Function

  • Has antibacterial activiy against Gram-negative and Gram-positive bacteria.

• ·Literature 1

• • Title

  • Properties of synthetic analogs of gramicidin S containing L-serine or L-glutamic acid residue in place of L-ornithine residue.

• • Pubmed ID

  • 8791160

• • Reference

  • Int J Pept Protein Res. 1996 May;47(5):369-375.

• • Author

  • Tamaki M, Akabori S, Muramatsu I.