General Information
-
DRAMP ID
- DRAMP04005
-
Peptide Name
- Gramicidin analogue ([Ser2,2']-GS)
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- VSLFPVSLFP
-
Sequence Length
- 10
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- Gram-positive bacteria: Streptococcus pyogenes N.Y.5 (MIC=25 µg/ml), Myotis flavus ATCC 10240 (MIC=12.5 µg/ml);
- Gram-negative bacteria: Corynebacterium diphtheriae P.W.8 (MIC=12.5 µg/ml).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP04005.
Physicochemical Information
-
Formula
- C56H84N10O13
Absent Amino Acids
- ACDEGHIKMNQRTWY
Common Amino Acids
- FLPSV
Mass
- 1105.34
PI
- 5.49
Basic Residues
- 0
Acidic Residues
- 0
Hydrophobic Residues
- 6
Net Charge
- 0
-
Boman Index
- 17.08
Hydrophobicity
- 1.68
Aliphatic Index
- 136
Half Life
-
- Mammalian:100 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 2
DRAMP04005
Comments Information
Function
- Has antibacterial activiy against Gram-negative and Gram-positive bacteria.
Literature Information
- ·Literature 1
-
Title
- Properties of synthetic analogs of gramicidin S containing L-serine or L-glutamic acid residue in place of L-ornithine residue.
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Pubmed ID
- 8791160
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Reference
- Int J Pept Protein Res. 1996 May;47(5):369-375.
-
Author
- Tamaki M, Akabori S, Muramatsu I.