• • DRAMP ID

  • DRAMP04011

• • Peptide Name

  • Plasticin PD36 KF (analog of PD36)

• • Source

  • Synthetic construct

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • GVVTDLLKTAGKLLGNLFGSLSG

• • Sequence Length

  • 23

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • [Ref.17128968]Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=6.5 µM), Bacillus megaterium ATCC 9885 (MIC=50.25 µM);
    • Gram-negative bacteria: Escherichia coli ATCC 11775 (MIC=6.5 µM), Salmonella typhimurium CIP 6062 (MIC=25.25 µM), Enterobacter cloacae ATCC 11775 (MIC=12.5 µM).

• • Hemolytic Activity

  • • [Ref.17128968]25% hemolytic at 50 μM, 50% hemolytic activity at 100 μM against rat red blood cells

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• Please click DRAMP04011_predicted_structure.pdb to download.

DRAMP04011

• • Function

  • Has antibacterial activiy. The hemolytic activity of the peptides was determined using fresh rat erythrocytes.

• ·Literature 1

• • Title

  • The plasticins: membrane adsortpion, lipid disorders, and biological activity.

• • Pubmed ID

  • 17128968

• • Reference

  • Biochemistry 2006; 45: 14285-14297.

• • Author

  • Amri CE et al Bruston F.