General Information
-
DRAMP ID
- DRAMP04014
-
Peptide Name
- LL-37A9 (LL-37 variants)
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Source
- Synthetic construct
-
Family
- Not found
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Gene
- Not found
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Sequence
- LLGDFFRKAKEKIGKEFKRIVQRIKDFLRNLVPRTES
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Sequence Length
- 37
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic
Activity Information
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Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram-
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Target Organism
-
- Gram-negative bacteria: Escherichia coli DC2 (MIC=6 µM), Escherichia coli K12 (MIC=15 µM).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- Please click DRAMP04014_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C205H340N60O52
Absent Amino Acids
- CHMWY
Common Amino Acids
- K
Mass
- 4477.33
PI
- 10.61
Basic Residues
- 11
Acidic Residues
- 5
Hydrophobic Residues
- 14
Net Charge
- +6
-
Boman Index
- -105.79
Hydrophobicity
- -0.654
Aliphatic Index
- 92.16
Half Life
-
- Mammalian:5.5 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 5
DRAMP04014
Comments Information
Function
- Has antibacterial activiy against the Gram-negative bacterium E. coli.
Literature Information
- ·Literature 1
-
Title
- Structure, dynamics, and antimicrobial and immune modulatory activities of human LL-23 and its single-residue variants mutated on the basis of homologous primate cathelicidins.
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Pubmed ID
- 22185690
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Reference
- Biochemistry. 2012 Jan 17;51(2):653-664.
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Author
- Wang G, Elliott M, Cogen AL, Ezell EL, Gallo RL, Hancock RE.