General Information

    • DRAMP ID

    • DRAMP04018

    • Peptide Name

    • Rp-1

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • ALYKKFKKKLLKSLKRLG

    • Sequence Length

    • 18

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-positive bacteria: Staphylococcus, Streptococcus, Bacillus species;
      • Gram-negative bacteria: Escherichia, Salmonella, Pseudomonas species.
      • Fungi: Candida and Cryptococcus species.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04018 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP04018.

Physicochemical Information

    • Formula

    • C104H184N28O21

    • Absent Amino Acids

    • CDEHIMNPQTVW

    • Common Amino Acids

    • K

    • Mass

    • 2162.78

    • PI

    • 10.82

    • Basic Residues

    • 8

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +8

    • Boman Index

    • -26.98

    • Hydrophobicity

    • -0.594

    • Aliphatic Index

    • 113.89

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 87.65

    • Polar Residues

    • 3

DRAMP04018

DRAMP04018 chydropathy plot

Comments Information

    • Function

    • Has antibacterial activiy against Gram-negative and Gram-positive bacteria and the yeast candian

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial peptide RP-1 structure and interactions with anionic versus zwitterionic micelles.

    • Reference

    • Biopolymers. 2009 Jan;91(1):1-13.

    • Author

    • Bourbigot S, Dodd E, Horwood C, Cumby N, Fardy L, Welch WH, Ramjan Z, Sharma S, Waring AJ, Yeaman MR, Booth V.