General Information

    • DRAMP ID

    • DRAMP04021

    • Peptide Name

    • Bac034 (Scrambled Variants of Bac2A)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • VRLRIRVAVIRA

    • Sequence Length

    • 12

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-negative bacteria: Pseudomonas aeruginosa (MIC=25 µg/ml), Escherichia coli (MIC=3 µg/ml), Salmonella (MIC=12 µg/ml);
      • Gram-positive bacteria: Staphylococcus aureus (MIC=25 µg/ml), Staphylococcus epidermidis (MIC=3 µg/ml).
      • Yeast: Candida albicans (MIC=12 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04021 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C63H120N24O13

    • Absent Amino Acids

    • CDEFGHKMNPQSTWY

    • Common Amino Acids

    • R

    • Mass

    • 1421.8

    • PI

    • 12.48

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +4

    • Boman Index

    • -29.18

    • Hydrophobicity

    • 0.917

    • Aliphatic Index

    • 186.67

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 0

DRAMP04021

Comments Information

    • Function

    • Has antibacterial activiy against Gram-negative and Gram-positive bacteria.

Literature Information

  • ·Literature 1

    • Title

    • Sequence requirements and an optimization strategy for short antimicrobial peptides.

    • Reference

    • Chem Biol. 2006 Oct;13(10):1101-1107.

    • Author

    • Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE.