• DRAMP ID

    • DRAMP04022
    • Peptide Name

    • F3 (single amino acid substitution of Bac034, which is a scrambled Variant of Bac2A)
    • Source

    • Synthetic construct
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • VRFRIRVAVIRA
    • Sequence Length

    • 12
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Synthetic
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
    • Target Organism

      • Gram-negative bacteria: Pseudomonas aeruginosa (MIC=6 µg/ml), Escherichia coli (MIC=1.6 µg/ml), Salmonella (MIC=6 µg/ml);
      • Gram-positive bacteria: Staphylococcus aureus (MIC=12 µg/ml), Staphylococcus epidermidis (MIC=1.6 µg/ml).
      • Yeast: Candida albicans (MIC=6 µg/ml).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP04022 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • Formula

    • C66H118N24O13
    • Absent Amino Acids

    • CDEGHKLMNPQSTWY
    • Common Amino Acids

    • R
    • Mass

    • 1455.82
    • PI

    • 12.48
    • Basic Residues

    • 4
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 8
    • Net Charge

    • +4
    • Boman Index

    • -31.12
    • Hydrophobicity

    • 0.833
    • Aliphatic Index

    • 154.17
    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 0

DRAMP04022

    • Function

    • Has antibacterial activiy against Gram-negative and Gram-positive bacteria.
  • ·Literature 1
    • Title

    • Sequence requirements and an optimization strategy for short antimicrobial peptides.
    • Reference

    • Chem Biol. 2006 Oct;13(10):1101-1107.
    • Author

    • Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE.