General Information
-
DRAMP ID
- DRAMP04022
-
Peptide Name
- F3 (single amino acid substitution of Bac034, which is a scrambled Variant of Bac2A)
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- VRFRIRVAVIRA
-
Sequence Length
- 12
-
UniProt Entry
- No entry found
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Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
-
- Gram-negative bacteria: Pseudomonas aeruginosa (MIC=6 µg/ml), Escherichia coli (MIC=1.6 µg/ml), Salmonella (MIC=6 µg/ml);
- Gram-positive bacteria: Staphylococcus aureus (MIC=12 µg/ml), Staphylococcus epidermidis (MIC=1.6 µg/ml).
- Yeast: Candida albicans (MIC=6 µg/ml).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- Please click DRAMP04022_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C66H118N24O13
Absent Amino Acids
- CDEGHKLMNPQSTWY
Common Amino Acids
- R
Mass
- 1455.82
PI
- 12.48
Basic Residues
- 4
Acidic Residues
- 0
Hydrophobic Residues
- 8
Net Charge
- +4
-
Boman Index
- -31.12
Hydrophobicity
- 0.833
Aliphatic Index
- 154.17
Half Life
-
- Mammalian:100 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 0
DRAMP04022
Comments Information
Function
- Has antibacterial activiy against Gram-negative and Gram-positive bacteria.
Literature Information
- ·Literature 1
-
Title
- Sequence requirements and an optimization strategy for short antimicrobial peptides.
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Pubmed ID
- 17052614
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Reference
- Chem Biol. 2006 Oct;13(10):1101-1107.
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Author
- Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE.