General Information
-
DRAMP ID
- DRAMP04024
-
Peptide Name
- W4 (single amino acid substitution of Bac034, which is a scrambled Variant of Bac2A)
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- VRLWIRVAVIRA
-
Sequence Length
- 12
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
-
- Gram-negative bacteria: Pseudomonas aeruginosa (MIC>50 µg/ml), Escherichia coli (MIC=6 µg/ml), Salmonella (MIC>50 µg/ml);
- Gram-positive bacteria: Staphylococcus aureus (MIC=50 µg/ml), Staphylococcus epidermidis (MIC=3 µg/ml).
- Yeast: Candida albicans (MIC=50 µg/ml).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP04024.
Physicochemical Information
-
Formula
- C68H118N22O13
Absent Amino Acids
- CDEFGHKMNPQSTY
Common Amino Acids
- RV
Mass
- 1451.82
PI
- 12.3
Basic Residues
- 3
Acidic Residues
- 0
Hydrophobic Residues
- 9
Net Charge
- +3
-
Boman Index
- -11.93
Hydrophobicity
- 1.217
Aliphatic Index
- 186.67
Half Life
-
- Mammalian:100 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 500
Polar Residues
- 0
DRAMP04024
Comments Information
Function
- Has antibacterial activiy against Gram-negative and Gram-positive bacteria.
Literature Information
- ·Literature 1
-
Title
- Sequence requirements and an optimization strategy for short antimicrobial peptides.
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Pubmed ID
- 17052614
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Reference
- Chem Biol. 2006 Oct;13(10):1101-1107.
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Author
- Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE.