• • DRAMP ID

  • DRAMP04025

• • Peptide Name

  • R10 (single amino acid substitution of Bac034, which is a scrambled Variant of Bac2A)

• • Source

  • Synthetic construct

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • VRLRIRVAVRRA

• • Sequence Length

  • 12

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

• • Target Organism

  • • Gram-negative bacteria: Pseudomonas aeruginosa (MIC=12 µg/ml), Escherichia coli (MIC=6 µg/ml), Salmonella (MIC=6 µg/ml);
    • Gram-positive bacteria: Staphylococcus aureus (MIC=12 µg/ml), Staphylococcus epidermidis (MIC=1.6 µg/ml).
    • Yeast: Candida albicans (MIC=6 µg/ml).

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• Please click DRAMP04025_predicted_structure.pdb to download.

DRAMP04025

• • Function

  • Has antibacterial activiy against Gram-negative and Gram-positive bacteria.

• ·Literature 1

• • Title

  • Sequence requirements and an optimization strategy for short antimicrobial peptides.

• • Pubmed ID

  • 17052614

• • Reference

  • Chem Biol. 2006 Oct;13(10):1101-1107.

• • Author

  • Hilpert K, Elliott MR, Volkmer-Engert R, Henklein P, Donini O, Zhou Q, Winkler DF, Hancock RE.