• DRAMP ID

    • DRAMP04034
    • Peptide Name

    • Modified defensin
    • Source

    • Synthetic construct
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • AWLLAIRKR
    • Sequence Length

    • 9
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Synthetic
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus (MIC=3 µg/ml), Staphylococcus aureus (MRSA) (MIC=25 µg/ml);
      • Gram-negative bacteria: Escherichia coli (MIC=5 µg/ml), Pseudomonas aeruginosa (MIC=4 µg/ml).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP04034 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP04034.
    • Formula

    • C53H91N17O10
    • Absent Amino Acids

    • CDEFGHMNPQSTVY
    • Common Amino Acids

    • ALR
    • Mass

    • 1126.41
    • PI

    • 12.01
    • Basic Residues

    • 3
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 6
    • Net Charge

    • +3
    • Boman Index

    • -14.68
    • Hydrophobicity

    • 0.211
    • Aliphatic Index

    • 152.22
    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 5500
    • Absorbance 280nm

    • 687.5
    • Polar Residues

    • 0

DRAMP04034

    • Function

    • Has antibacterial activiy against Gram-negative and Gram-positive bacteria.
  • ·Literature 1
    • Title

    • Purification, cDNA cloning and modification of a defensin from the coconut rhinoceros beetle, Oryctes rhinoceros.
    • Reference

    • Eur J Biochem. 1999 Dec;266(2):616-623.
    • Author

    • Ishibashi J, Saido-Sakanaka H, Yang J, Sagisaka A, Yamakawa M.