General Information

    • DRAMP ID

    • DRAMP04035

    • Peptide Name

    • Modified defensin

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • ALYLAIRKR

    • Sequence Length

    • 9

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus (MIC=3 µg/ml), Staphylococcus aureus (MRSA) (MIC=30 µg/ml);
      • Gram-negative bacteria: Escherichia coli (MIC=4 µg/ml), Pseudomonas aeruginosa (MIC=4 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04035 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP04035.

Physicochemical Information

    • Formula

    • C51H90N16O11

    • Absent Amino Acids

    • CDEFGHMNPQSTVW

    • Common Amino Acids

    • ALR

    • Mass

    • 1103.38

    • PI

    • 11

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 5

    • Net Charge

    • +3

    • Boman Index

    • -17.15

    • Hydrophobicity

    • 0.167

    • Aliphatic Index

    • 152.22

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 186.25

    • Polar Residues

    • 1

DRAMP04035

Comments Information

    • Function

    • Has antibacterial activiy against Gram-negative and Gram-positive bacteria.

Literature Information

  • ·Literature 1

    • Title

    • Purification, cDNA cloning and modification of a defensin from the coconut rhinoceros beetle, Oryctes rhinoceros.

    • Reference

    • Eur J Biochem. 1999 Dec;266(2):616-623.

    • Author

    • Ishibashi J, Saido-Sakanaka H, Yang J, Sagisaka A, Yamakawa M.