• • DRAMP ID

  • DRAMP04048

• • Peptide Name

  • BacR (cyclic derivative of bactenecin)

• • Source

  • Synthetic construct

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • RRLCRIVVIRVCRR

• • Sequence Length

  • 14

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • Gram-negative bacteria: Escherichia coli K-12 (MIC=2 µg/ml), Pseudomonas aeruginosa K799 (MIC=4 µg/ml), Salmonella typhimurium 14028s (MIC=4 µg/ml);
    • Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=64 µg/ml), Staphylococcus epidermidis C621 (MIC=8 µg/ml), Enterococcus faecalis ATCC 29212 (MIC=32 µg/ml), Listeria monocytogenes (MIC<0.125 µg/ml), Corynebacterium xerosis (MIC=1 µg/ml), Streptococcus pyogenes ATCC 19615 (MIC=8 µg/ml), S. mitis (MIC=0.5 µg/ml), Streptococcus pneumoniae ATCC 49619 (MIC>64 µg/ml).

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Cyclic

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Free

• • Nonterminal Modifications and Unusual Amino Acids

  • Disulfide bond between Cys4 and Cys12.

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• Please click DRAMP04048_predicted_structure.pdb to download.

DRAMP04048

• • Function

  • Has antibacterial activiy against Gram-negative and Gram-positive bacteria.

• ·Literature 1

• • Title

  • Improved derivatives of bactenecin, a cyclic dodecameric antimicrobial cationic peptide.

• • Pubmed ID

  • 10223951

• • Reference

  • Antimicrob Agents Chemother. 1999 May;43(5):1274-1276.

• • Author

  • Wu M, Hancock RE.