General Information
-
DRAMP ID
- DRAMP04055
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Peptide Name
- BacW2R (cyclic derivative of bactenecin)
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Source
- Synthetic construct
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Family
- Not found
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Gene
- Not found
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Sequence
- RRLCRIVWVIRVCRR
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Sequence Length
- 15
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UniProt Entry
- No entry found
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Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- Gram-negative bacteria: Escherichia coli K-12 (MIC=2 µg/ml), Pseudomonas aeruginosa K799 (MIC=2 µg/ml), Salmonella typhimurium 14028s (MIC=2 µg/ml);
- Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=2 µg/ml), Staphylococcus epidermidis C621 (MIC=1 µg/ml), Enterococcus faecalis ATCC 29212 (MIC=2 µg/ml), Listeria monocytogenes (MIC=0.25 µg/ml), Corynebacterium xerosis (MIC=0.25 µg/ml), Streptococcus pyogenes ATCC 19615 (MIC=1 µg/ml), S. mitis (MIC=0.25 µg/ml), Streptococcus pneumoniae ATCC 49619 (MIC=8 µg/ml).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP04055.
Physicochemical Information
-
Formula
- C86H154N34O16S2
Absent Amino Acids
- ADEFGHKMNPQSTY
Common Amino Acids
- R
Mass
- 1984.51
PI
- 12
Basic Residues
- 6
Acidic Residues
- 0
Hydrophobic Residues
- 7
Net Charge
- +6
-
Boman Index
- -57.75
Hydrophobicity
- 0.167
Aliphatic Index
- 136
Half Life
-
- Mammalian:1 hour
- Yeast:2 min
- E.coli:2 min
Extinction Coefficient Cystines
- 5625
Absorbance 280nm
- 401.79
Polar Residues
- 2
DRAMP04055
Comments Information
Function
- Has antibacterial activiy against Gram-negative and Gram-positive bacteria.
Literature Information
- ·Literature 1
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Title
- Improved derivatives of bactenecin, a cyclic dodecameric antimicrobial cationic peptide.
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Pubmed ID
- 10223951
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Reference
- Antimicrob Agents Chemother. 1999 May;43(5):1274-1276.
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Author
- Wu M, Hancock RE.