General Information
-
DRAMP ID
- DRAMP04056
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Peptide Name
- Lin Bac2S-NH2 (linear derivative of bactenecin)
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Source
- Synthetic construct
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Family
- Not found
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Gene
- Not found
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Sequence
- RLSRIVVIRVSR
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Sequence Length
- 12
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UniProt Entry
- No entry found
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Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- Gram-negative bacteria: Escherichia coli K-12 (MIC=2 µg/ml), Pseudomonas aeruginosa K799 (MIC=16 µg/ml), Salmonella typhimurium 14028s (MIC=32 µg/ml);
- Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=4 µg/ml), Staphylococcus epidermidis C621 (MIC=1 µg/ml), Enterococcus faecalis ATCC 29212 (MIC=4 µg/ml), Listeria monocytogenes (MIC=0.25 µg/ml), Corynebacterium xerosis (MIC=0.25 µg/ml), Streptococcus pyogenes ATCC 19615 (MIC=2 µg/ml), S. mitis (MIC=0.125 µg/ml), Streptococcus pneumoniae ATCC 49619 (MIC=16 µg/ml)
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- Please click DRAMP04056_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C63H120N24O15
Absent Amino Acids
- ACDEFGHKMNPQTWY
Common Amino Acids
- R
Mass
- 1453.8
PI
- 12.48
Basic Residues
- 4
Acidic Residues
- 0
Hydrophobic Residues
- 6
Net Charge
- +4
-
Boman Index
- -39.6
Hydrophobicity
- 0.483
Aliphatic Index
- 170
Half Life
-
- Mammalian:1 hour
- Yeast:2 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 2
DRAMP04056
Comments Information
Function
- Has antibacterial activiy against Gram-negative and Gram-positive bacteria.
Literature Information
- ·Literature 1
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Title
- Improved derivatives of bactenecin, a cyclic dodecameric antimicrobial cationic peptide.
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Pubmed ID
- 10223951
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Reference
- Antimicrob Agents Chemother. 1999 May;43(5):1274-1276.
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Author
- Wu M, Hancock RE.