• DRAMP ID

    • DRAMP04057
    • Peptide Name

    • Lin BacS-NH2 (linear derivative of bactenecin)
    • Source

    • Synthetic construct
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • RLSRIVVIRVCR
    • Sequence Length

    • 12
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Synthetic
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • Gram-negative bacteria: Escherichia coli K-12 (MIC=4 µg/ml), Pseudomonas aeruginosa K799 (MIC=16 µg/ml), Salmonella typhimurium 14028s (MIC>64 µg/ml);
      • Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=16 µg/ml), Staphylococcus epidermidis C621 (MIC=2 µg/ml), Enterococcus faecalis ATCC 29212 (MIC=16 µg/ml), Listeria monocytogenes (MIC=0.5 µg/ml), Corynebacterium xerosis (MIC=0.5 µg/ml), Streptococcus pyogenes ATCC 19615 (MIC=8 µg/ml), S. mitis (MIC=0.5 µg/ml), Streptococcus pneumoniae ATCC 49619 (MIC=8 µg/ml).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP04057 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • Formula

    • C63H120N24O14S
    • Absent Amino Acids

    • ADEFGHKMNPQTWY
    • Common Amino Acids

    • R
    • Mass

    • 1469.86
    • PI

    • 12
    • Basic Residues

    • 4
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 6
    • Net Charge

    • +4
    • Boman Index

    • -34.92
    • Hydrophobicity

    • 0.758
    • Aliphatic Index

    • 170
    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 2

DRAMP04057

    • Function

    • Has antibacterial activiy against Gram-negative and Gram-positive bacteria.
  • ·Literature 1
    • Title

    • Improved derivatives of bactenecin, a cyclic dodecameric antimicrobial cationic peptide.
    • Reference

    • Antimicrob Agents Chemother. 1999 May;43(5):1274-1276.
    • Author

    • Wu M, Hancock RE.