General Information

    • DRAMP ID

    • DRAMP04067

    • Peptide Name

    • Cyclic cationic V4 peptide

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • CVKVQVKVGSGVKVQVKVC

    • Sequence Length

    • 19

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • [Ref.15328096]Gram-negative bacteria: Escherichia coli ATTC 25922 (MIC=10 nM), Pseudomonas aeruginosa ATTC 27853 (MIC=5 nM), Klebsiella pneumoniae ATTC 13883 (MIC<5 nM), Salmonella enterica serovar Typhimurium ATTC 14028 (MIC=5 nM), Shigella sonnei ATTC 25931 (MIC=10 nM).

    • Hemolytic Activity

      • [Ref.15328096]EC50=3226000 nM against human erythrocytes

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04067 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP04067.

Physicochemical Information

    • Formula

    • C87H159N25O23S2

    • Absent Amino Acids

    • ADEFHILMNPRTWY

    • Common Amino Acids

    • V

    • Mass

    • 1987.49

    • PI

    • 9.7

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +4

    • Boman Index

    • 0.08

    • Hydrophobicity

    • 0.758

    • Aliphatic Index

    • 122.11

    • Half Life

      • Mammalian:1.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 6.94

    • Polar Residues

    • 5

DRAMP04067

DRAMP04067 chydropathy plot

Comments Information

    • Function

    • Has antibacterial activiy. Has hemolytic activity for human erythrocytes, and also Cytotoxic activity for THP-1 cells (EC50=0.047 mM).

Literature Information

  • ·Literature 1

    • Title

    • De Novo Design of Potent Antimicrobial Peptides.

    • Reference

    • Antimicrob Agents Chemother. 2004 Sep;48(9):3349-3357.

    • Author

    • Frecer V, Ho B, Ding JL.