• • DRAMP ID

  • DRAMP04076

• • Peptide Name

  • Anal 1 (antimicrobial peptide HP (2-20)analogue)

• • Source

  • Synthetic construct (amino acid substitution)

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • AKKVFKRLEKLFSKIQNWK

• • Sequence Length

  • 19

• • UniProt Entry

  • P56029

• • Protein Existence

  • Synthetic

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

• • Target Organism

  • • Gram-positive bacteria: Bacillus subtilis (MIC=1.56 µg/ml), Staphylococcus epidermidis (MIC=3.13 µg/ml), Staphylococcus aureus (MIC=3.13 µg/ml), Listeria monocytogenes (MIC=0.78 µg/ml);
    • Gram-negative bacteria: Escherichia coli (MIC=0.78 µg/ml), Salmonella typhimurium (MIC=0.39 µg/ml), Proteus vulgaris (MIC=3.13 µg/ml), Pseudomonas aeruginosa (MIC=3.13 µg/ml), Escherichia coli O157 (MIC=6.25 µg/ml).
    • Fungi: Trichosporon beigelii (MIC=1.56 µg/ml), Candida albicans (MIC=25 µg/ml), Saccharomyces cerevisiae (MIC=25 µg/ml), Aspergillus flavus (MIC=50 µg/ml), Aspergillus fumigatus (MIC>50 µg/ml), Botrytis cinerea (MIC=6.25 µg/ml), Fusarium moniliforme (MIC=12.5 µg/ml).

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Alpha helix (1 helices; 14 residues)

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • 1P0J resolved by NMR.

• Predicted Structure

• There is no predicted structure for DRAMP04076.

DRAMP04076

• • Function

  • Has antibacterial and antifungal activiy.

• ·Literature 1

• • Title

  • Interactions between the plasma membrane and the antimicrobial peptide HP (2-20) and its analogues derived from Helicobacter pylori.

• • Pubmed ID

  • 16255716

• • Reference

  • Biochem J. 2006 Feb 15;394(Pt 1):105-114.

• • Author

  • Lee KH, Lee DG, Park Y, Kang DI, Shin SY, Hahm KS, Kim Y.

• ·Literature 2

• • Title

  • Interactions between antimicrobial peptide, HP(2-20) derived from helicobacter pylori, and membrain studied by nmr spectroscopy.

• • Pubmed ID

  • PubMed ID is not available

• • Reference

  • To be published

• • Author

  • Lee KH, Lee DG, Park YK, Harm KS, Kim YM.