General Information
-
DRAMP ID
- DRAMP04082
-
Peptide Name
- Anal 7 (antimicrobial peptide HP (2-20)analogue)
-
Source
- Synthetic construct (amino acid substitution)
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- AKKVFKRLEKLFSKIYNYK
-
Sequence Length
- 19
-
UniProt Entry
- P56029
-
Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
-
Target Organism
-
- Gram-positive bacteria: Bacillus subtilis (MIC=1.56 µg/ml), Staphylococcus epidermidis (MIC=3.13 µg/ml), Staphylococcus aureus (MIC=3.13 µg/ml), Listeria monocytogenes (MIC=0.78 µg/ml);
- Gram-negative bacteria: Escherichia coli (MIC=3.13 µg/ml), Salmonella typhimurium (MIC=0.39 µg/ml), Proteus vulgaris (MIC=6.25-3.13 µg/ml), Pseudomonas aeruginosa (MIC=3.13 µg/ml), Escherichia coli O157 (MIC=3.13 µg/ml).
- Fungi: Trichosporon beigelii (MIC=1.56 µg/ml), Candida albicans (MIC=12.5 µg/ml), Saccharomyces cerevisiae (MIC=25 µg/ml), Aspergillus flavus (MIC=50 µg/ml), Aspergillus fumigatus (MIC=50-25 µg/ml), Botrytis cinerea (MIC=6.25 µg/ml), Fusarium moniliforme (MIC=12.5 µg/ml).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Alpha helix
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- Please click DRAMP04082_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C116H187N29O26
Absent Amino Acids
- CDGHMPQTW
Common Amino Acids
- K
Mass
- 2403.94
PI
- 10.22
Basic Residues
- 7
Acidic Residues
- 1
Hydrophobic Residues
- 7
Net Charge
- +6
-
Boman Index
- -38.78
Hydrophobicity
- -0.768
Aliphatic Index
- 82.11
Half Life
-
- Mammalian:4.4 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 2980
Absorbance 280nm
- 165.56
Polar Residues
- 4
DRAMP04082
Comments Information
Function
- Has antibacterial and antifungal activiy.
Literature Information
- ·Literature 1
-
Title
- Interactions between the plasma membrane and the antimicrobial peptide HP (2-20) and its analogues derived from Helicobacter pylori.
-
Pubmed ID
- 16255716
-
Reference
- Biochem J. 2006 Feb 15;394(Pt 1):105-114.
-
Author
- Lee KH, Lee DG, Park Y, Kang DI, Shin SY, Hahm KS, Kim Y.
- ·Literature 2
-
Title
- Interactions between antimicrobial peptide, HP(2-20) derived from helicobacter pylori, and membrain studied by nmr spectroscopy.
-
Pubmed ID
- PubMed ID is not available
-
Reference
- To be published
-
Author
- Lee KH, Lee DG, Park YK, Harm KS, Kim YM.