General Information

    • DRAMP ID

    • DRAMP04083

    • Peptide Name

    • D-amino-acid pexiganan (MSI-214)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GIGKFLKKAKKFGKAFVKILKK

    • Sequence Length

    • 22

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MIC=16 µg/ml), Enterococcus faecium ATCC 51559 (vancomycin resistant) (MIC=4 µg/ml), Enterococcus faecalis ATCC 29212 (MIC=16 µg/ml), Streptococcus bovis ATCC 49133 (MIC=4 µg/ml), Micrococcus luteus ATCC 4698 (MIC=2-4 µg/ml);
      • Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=8-16 µg/ml), Proteus mirabilis ATCC 29245 (MIC>256 µg/ml), Serratia marcescens ATCC 8100 (MIC>256 µg/ml), Pseudomonas aeruginosa ATCC 27853 (MIC=16-32 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04083 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP04083.

Physicochemical Information

    • Formula

    • C122H209N31O23

    • Absent Amino Acids

    • CDEHMNPQRSTWY

    • Common Amino Acids

    • K

    • Mass

    • 2478.2

    • PI

    • 10.9

    • Basic Residues

    • 9

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +9

    • Boman Index

    • -10.85

    • Hydrophobicity

    • -0.159

    • Aliphatic Index

    • 93.18

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP04083

DRAMP04083 chydropathy plot

Comments Information

    • MSI-214 is a peptide identical in sequence to pexiganan but comprising all D-amino acids.

Literature Information

  • ·Literature 1

    • Title

    • In vitro antibacterial properties of pexiganan, an analog of magainin.

    • Reference

    • Antimicrob Agents Chemother. 1999 Apr;43(4):782-788.

    • Author

    • Ge Y, MacDonald DL, Holroyd KJ, Thornsberry C, Wexler H, Zasloff M.