General Information

    • DRAMP ID

    • DRAMP04097

    • Peptide Name

    • 2IQ3

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • DNTDSVVKIQSWFRMATARKSYL

    • Sequence Length

    • 23

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-negative bacterium: Escherichia coli (MIC=1.2 µM);
      • Gram-positive bacterium: Staphylococcus aureus (MIC=26 µM).
      • Yeast: Candida albicans (MIC=25 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04097 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C120H190N34O36S

    • Absent Amino Acids

    • CEGHP

    • Common Amino Acids

    • S

    • Mass

    • 2717.09

    • PI

    • 9.7

    • Basic Residues

    • 4

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +2

    • Boman Index

    • -56.84

    • Hydrophobicity

    • -0.513

    • Aliphatic Index

    • 67.83

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 6990

    • Absorbance 280nm

    • 317.73

    • Polar Residues

    • 7

DRAMP04097

DRAMP04097 chydropathy plot

Comments Information

    • Function

    • Displays antimicrobial activity against bacteria and yeast C. albicans.

Literature Information

  • ·Literature 1

    • Title

    • IQ-motif peptides as novel anti-microbial agents.

    • Reference

    • Biochimie. 2013 Apr;95(4):875-880.

    • Author

    • McLean DT, Lundy FT, Timson DJ.