General Information

    • DRAMP ID

    • DRAMP04099

    • Peptide Name

    • 3IQ2

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • TWLPAVIKIQAHWRGYRQRKIYL

    • Sequence Length

    • 23

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-negative bacterium: Escherichia coli (MIC=1.9 µM);
      • Gram-positive bacterium: Staphylococcus aureus (MIC=1.6 µM).
      • Yeast: Candida albicans (MIC=25 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04099 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C138H214N40O29

    • Absent Amino Acids

    • CDEFMNS

    • Common Amino Acids

    • IR

    • Mass

    • 2897.47

    • PI

    • 11.07

    • Basic Residues

    • 6

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +6

    • Boman Index

    • -36.59

    • Hydrophobicity

    • -0.422

    • Aliphatic Index

    • 106.09

    • Half Life

      • Mammalian:7.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 13980

    • Absorbance 280nm

    • 635.45

    • Polar Residues

    • 4

DRAMP04099

DRAMP04099 chydropathy plot

Comments Information

    • Function

    • Displays antimicrobial activity against bacteria and yeast C. albicans.

Literature Information

  • ·Literature 1

    • Title

    • IQ-motif peptides as novel anti-microbial agents.

    • Reference

    • Biochimie. 2013 Apr;95(4):875-880.

    • Author

    • McLean DT, Lundy FT, Timson DJ.