General Information
-
DRAMP ID
- DRAMP04103
-
Peptide Name
- S16 (derivative of CP-P)
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- KWKSFIKKLTSKFLHSAKKF
-
Sequence Length
- 20
-
UniProt Entry
- No entry found
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Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram-
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Target Organism
-
- Gram-negative bacterium: Pseudomonas aeruginosa (MIC=3.125 µg/ml).
- Clinical isolates: Acinetobacter baumannii b-01 (MIC=3.125 µg/mL), Acinetobacter baumannii b-02 (MIC=6.25 µg/mL), Acinetobacter baumannii b-03 (MIC=6.25 µg/mL), Acinetobacter baumannii b-04 (MIC=3.125 µg/mL).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
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Structure
- Not found
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP04103.
Physicochemical Information
-
Formula
- C120H190N30O25
Absent Amino Acids
- CDEGMNPQRVY
Common Amino Acids
- K
Mass
- 2453.01
PI
- 10.78
Basic Residues
- 8
Acidic Residues
- 0
Hydrophobic Residues
- 8
Net Charge
- +8
-
Boman Index
- -28.44
Hydrophobicity
- -0.61
Aliphatic Index
- 63.5
Half Life
-
- Mammalian:1.3 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 289.47
Polar Residues
- 4
DRAMP04103
Comments Information
Function
- Has antibacterial activity.
Literature Information
- ·Literature 1
-
Title
- The Design and Construction of K11: A Novel α-Helical Antimicrobial Peptide.
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Pubmed ID
- 22518150
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Reference
- Int J Microbiol. 2012;2012:764834.
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Author
- Jin-Jiang H, Jin-Chun L, Min L, Qing-Shan H, Guo-Dong L.