General Information

    • DRAMP ID

    • DRAMP04129

    • Peptide Name

    • D6-NH2 (Derived from D0)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • RKKRWWRRKK

    • Sequence Length

    • 10

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.22518150] Gram-negative bacteria: Escherichia coli (MIC=3±0.07 µM), Pseudomonas aeruginosa ATCC 27853 (MIC=3±0.012 µM);
      • Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC=6±0.012 µM).

    • Hemolytic Activity

      • [Ref.23860860] 6.5% hemolysis at 100 μM against human red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04129 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP04129.

Physicochemical Information

    • Formula

    • C70H118N28O11

    • Absent Amino Acids

    • ACDEFGHILMNPQSTVY

    • Common Amino Acids

    • KR

    • Mass

    • 1527.89

    • PI

    • 12.48

    • Basic Residues

    • 8

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 2

    • Net Charge

    • +8

    • Boman Index

    • -77.22

    • Hydrophobicity

    • -3.54

    • Aliphatic Index

    • 0

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 11000

    • Absorbance 280nm

    • 1222.22

    • Polar Residues

    • 0

DRAMP04129

Comments Information

    • Function

    • Antibacterial activity against Gram-positive and Gram-negative bacteria.

    • Chemical modification

    • C-terminal amidation.

Literature Information

  • ·Literature 1

    • Title

    • The Design and Construction of K11: A Novel α-Helical Antimicrobial Peptide.

    • Reference

    • Int J Microbiol. 2012;2012:764834.

    • Author

    • Jin-Jiang H, Jin-Chun L, Min L, Qing-Shan H, Guo-Dong L.
  • ·Literature 2

    • Title

    • Design of Short Membrane Selective Antimicrobial Peptides Containing Tryptophan and Arginine Residues for Improved Activity, Salt-Resistance, and Biocompatibility

    • Reference

    • Biotechnol Bioeng. 2014 Jan;111(1):37-49. doi: 10.1002/bit.25003.

    • Author

    • Saravanan R, Li X, Lim K, Mohanram H, Peng L, Mishra B, Basu A, Lee JM, Bhattacharjya S, Leong SS.