General Information

    • DRAMP ID

    • DRAMP04133

    • Peptide Name

    • LK3 (Temporin-1CEa analog peptide)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FKKLKKIANIINSIFKK

    • Sequence Length

    • 17

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Anti-cancer

    • Target Organism

      • Cancer cell lines: MCF-7 (IC50=27.72 µM), MDA-MB-231 (IC50=224.8 µM), Bcap-37 (IC50=25.04 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04133 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP04133.

Physicochemical Information

    • Formula

    • C98H169N25O21

    • Absent Amino Acids

    • CDEGHMPQRTVWY

    • Common Amino Acids

    • K

    • Mass

    • 2033.57

    • PI

    • 10.7

    • Basic Residues

    • 6

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +6

    • Boman Index

    • -17.61

    • Hydrophobicity

    • -0.118

    • Aliphatic Index

    • 120.59

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP04133

Comments Information

    • Function

    • Has anticancer activity.

Literature Information

  • ·Literature 1

    • Title

    • Design of potent, non-toxic anticancer peptides based on the structure of the antimicrobial peptide, temporin-1CEa.

    • Reference

    • Arch Pharm Res. 2013 Apr 23.

    • Author

    • Yang QZ, Wang C, Lang L, Zhou Y, Wang H, Shang DJ.