• DRAMP ID

    • DRAMP04134
    • Peptide Name

    • LK2(6)A(L) (Temporin-1CEa analog peptide)
    • Source

    • Synthetic construct
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • FVKLKKILNIINSIFKK
    • Sequence Length

    • 17
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Synthetic
    • Biological Activity

    • Anti-cancer
    • Target Organism

      • Cancer cell lines: MCF-7 (IC50=9.01 µM), MDA-MB-231 (IC50=34.74 µM), Bcap-37 (IC50=10.52 µM).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP04134 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP04134.
    • Formula

    • C100H172N24O21
    • Absent Amino Acids

    • ACDEGHMPQRTWY
    • Common Amino Acids

    • K
    • Mass

    • 2046.61
    • PI

    • 10.6
    • Basic Residues

    • 5
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 9
    • Net Charge

    • +5
    • Boman Index

    • -4.91
    • Hydrophobicity

    • 0.477
    • Aliphatic Index

    • 154.71
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 3

DRAMP04134

    • Function

    • Has anticancer activity.
  • ·Literature 1
    • Title

    • Design of potent, non-toxic anticancer peptides based on the structure of the antimicrobial peptide, temporin-1CEa.
    • Reference

    • Arch Pharm Res. 2013 Apr 23.
    • Author

    • Yang QZ, Wang C, Lang L, Zhou Y, Wang H, Shang DJ.