General Information

    • DRAMP ID

    • DRAMP04136

    • Peptide Name

    • LRR-1

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • LRRLWLRANRL

    • Sequence Length

    • 11

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-negative bacteria: E. coli ATCC 25922 (MIC=128 µM), P. aeruginosa ATCC 27853 (MIC>128 µM), S. typhimurium C7731 (MIC>128 µM);
      • Gram-positive bacteria: S. epidermidis ATCC12228 (MIC>128 µM), E. faecalis ATCC 29212 (MIC>128 µM), S. aureus ATCC 29213 (MIC=128 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04136 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP04136.

Physicochemical Information

    • Formula

    • C66H115N25O13

    • Absent Amino Acids

    • CDEFGHIKMPQSTVY

    • Common Amino Acids

    • LR

    • Mass

    • 1466.8

    • PI

    • 12.48

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +4

    • Boman Index

    • -42.5

    • Hydrophobicity

    • -0.491

    • Aliphatic Index

    • 150.91

    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 550

    • Polar Residues

    • 1

DRAMP04136

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Rational design of cationic antimicrobial peptides by the tandem of leucine-rich repeat.

    • Reference

    • Amino Acids. 2013 Apr;44(4):1215-1224.

    • Author

    • Ma QQ, Lv YF, Gu Y, Dong N, Li DS, Shan AS.