General Information

    • DRAMP ID

    • DRAMP04147

    • Peptide Name

    • L10

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • WFRKQLKW

    • Sequence Length

    • 8

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-negative bacteria: Escherichia coli ATCC 25923 (MIC=0.8 µM), Klebsiella pneumoniae (MIC=3.35 µM), Acinetobacter sp. (MIC=3.35 µM), Psudomonas aruginosa (MIC=6.71 µM).
      • Fungi: Candida albicans ATCC SC5314 (MIC=10.49 µM), C. tropicalis ATCC 13803 (MIC=20.98 µM), C. parapsilosis ATCC 22019 (MIC=5.24 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Lipopolysaccharide (LPS)-binding

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04147 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP04147.

Physicochemical Information

    • Formula

    • C60H86N16O10

    • Absent Amino Acids

    • ACDEGHIMNPSTVY

    • Common Amino Acids

    • KW

    • Mass

    • 1191.44

    • PI

    • 11.17

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +3

    • Boman Index

    • -19

    • Hydrophobicity

    • -1.375

    • Aliphatic Index

    • 48.75

    • Half Life

      • Mammalian:2.8 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 11000

    • Absorbance 280nm

    • 1571.43

    • Polar Residues

    • 0

DRAMP04147

Comments Information

    • Function

    • Has antibacterial and antifungal activity.

Literature Information

  • ·Literature 1

    • Title

    • A novel antimicrobial peptide derived from modified N-terminal domain of bovine lactoferrin: Design, synthesis, activity against multidrug-resistant bacteria and Candida.

    • Reference

    • Biochim Biophys Acta. 2013 Feb;1828(2):677-686.

    • Author

    • Mishra B, Leishangthem GD, Gill K, Singh AK, Das S, Singh K, Xess I, Dinda A, Kapil A, Patro IK, Dey S.