General Information
-
DRAMP ID
- DRAMP04159
-
Peptide Name
- LR2 (homologue of Pc-CATH1)
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- RIKRFWPVVIRTVVAGYNLYRAIKK
-
Sequence Length
- 25
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
-
Target Organism
-
- Gram-positive bacteria: Bacillus subtilis (MIC=4.688 µg/ml), Staphylococcus aureus ATCC25923 (MIC=9.375 µg/ml).
- Gram-negative bacterium: Escherichia coli ATCC25922 (MIC=3.516 µg/ml).
- Yeast: Candida albicans ATCC2002 (MIC=2.344 µg/ml).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- Please click DRAMP04159_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C145H236N42O30
Absent Amino Acids
- CDEHMQS
Common Amino Acids
- RV
Mass
- 3047.73
PI
- 11.59
Basic Residues
- 7
Acidic Residues
- 0
Hydrophobic Residues
- 12
Net Charge
- +7
-
Boman Index
- -40.11
Hydrophobicity
- 0.044
Aliphatic Index
- 116.8
Half Life
-
- Mammalian:1 hour
- Yeast:2 min
- E.coli:2 min
Extinction Coefficient Cystines
- 8480
Absorbance 280nm
- 353.33
Polar Residues
- 5
DRAMP04159
Comments Information
Comment
- No comments found on DRAMP database
Literature Information
- ·Literature 1
-
Title
- Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1.
-
Pubmed ID
- PubMed ID is not available
-
Reference
- Natural Products and Bioprospecting. 2012 Apr;2(2):81-86.
-
Author
- Li Dong, Juan-Juan Yang, Ying Wang, Huan Liu, Li-Xian Mu, Dong-Hai Lin, Ren Lai.