General Information
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DRAMP ID
- DRAMP04160
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Peptide Name
- LR3 (homologue of Pc-CATH1)
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Source
- Synthetic construct
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Family
- Not found
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Gene
- Not found
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Sequence
- RIKRFWPVVIRTVVAGYNLYRAIK
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Sequence Length
- 24
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UniProt Entry
- No entry found
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Protein Existence
- Synthetic
Activity Information
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Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
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- Gram-positive bacteria: Bacillus subtilis (MIC=4.688 µg/ml), Staphylococcus aureus ATCC25923 (MIC=7.032 µg/ml).
- Gram-negative bacterium: Escherichia coli ATCC25922 (MIC=2.344 µg/ml).
- Yeast: Candida albicans ATCC2002 (MIC=0.586 µg/ml).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
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Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
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PDB ID
- None
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Predicted Structure
- Please click DRAMP04160_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C139H224N40O29
Absent Amino Acids
- CDEHMQS
Common Amino Acids
- RV
Mass
- 2919.56
PI
- 11.58
Basic Residues
- 6
Acidic Residues
- 0
Hydrophobic Residues
- 12
Net Charge
- +6
-
Boman Index
- -34.56
Hydrophobicity
- 0.208
Aliphatic Index
- 121.67
Half Life
-
- Mammalian:1 hour
- Yeast:2 min
- E.coli:2 min
Extinction Coefficient Cystines
- 8480
Absorbance 280nm
- 368.7
Polar Residues
- 5
DRAMP04160
Comments Information
Comment
- No comments found on DRAMP database
Literature Information
- ·Literature 1
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Title
- Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1.
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Pubmed ID
- PubMed ID is not available
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Reference
- Natural Products and Bioprospecting. 2012 Apr;2(2):81-86.
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Author
- Li Dong, Juan-Juan Yang, Ying Wang, Huan Liu, Li-Xian Mu, Dong-Hai Lin, Ren Lai.