General Information

    • DRAMP ID

    • DRAMP04161

    • Peptide Name

    • LR4 (homologue of Pc-CATH1)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • RIKRFWPVVIRTVVAGYNLYRAI

    • Sequence Length

    • 23

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-positive bacteria: Bacillus subtilis (MIC=37.5 µg/ml), Staphylococcus aureus ATCC25923 (MIC=37.5 µg/ml).
      • Gram-negative bacterium: Escherichia coli ATCC25922 (MIC=9.375 µg/ml).
      • Yeast: Candida albicans ATCC2002 (MIC=2.344 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04161 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C133H212N38O28

    • Absent Amino Acids

    • CDEHMQS

    • Common Amino Acids

    • RV

    • Mass

    • 2791.38

    • PI

    • 11.57

    • Basic Residues

    • 5

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +5

    • Boman Index

    • -29.01

    • Hydrophobicity

    • 0.387

    • Aliphatic Index

    • 126.96

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 8480

    • Absorbance 280nm

    • 385.45

    • Polar Residues

    • 5

DRAMP04161

DRAMP04161 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Structure-function relationship of antimicrobial peptide cathelicidin Pc-CATH1.

    • Reference

    • Natural Products and Bioprospecting. 2012 Apr;2(2):81-86.

    • Author

    • Li Dong, Juan-Juan Yang, Ying Wang, Huan Liu, Li-Xian Mu, Dong-Hai Lin, Ren Lai.