General Information

    • DRAMP ID

    • DRAMP04173

    • Peptide Name

    • L2KW2 (LlKmW2 model peptides)

    • Source

    • Synthetic construct (De novo design)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • WLLKW

    • Sequence Length

    • 5

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacteria: B. subtilis (MIC>80 µg/ml), S. aureus (MIC>80 µg/ml), S. epidermis (MIC>80 µg/ml), M. luteus (MIC>80 µg/ml), S. aureus (MRSA) (MIC>80 µg/ml).
      • Gram-negative bacteria: E. coli (MIC>80 µg/ml), S. dysentariae (MIC>80 µg/ml), S. typhimorium (MIC>80 µg/ml), K. pneumoniae (MIC>80 µg/ml), P. aeruginosa (MIC>80 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04173 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP04173.

Physicochemical Information

    • Formula

    • C40H56N8O6

    • Absent Amino Acids

    • ACDEFGHIMNPQRSTVY

    • Common Amino Acids

    • LW

    • Mass

    • 744.93

    • PI

    • 8.75

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +1

    • Boman Index

    • 8.95

    • Hydrophobicity

    • 0.38

    • Aliphatic Index

    • 156

    • Half Life

      • Mammalian:2.8 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 11000

    • Absorbance 280nm

    • 2750

    • Polar Residues

    • 0

DRAMP04173

Comments Information

    • Function

    • Has antimicrobial activities against Gram-negative and Gram-positive bacteria, including a multi-drug resistant strain.

    • Chemical modification

    • C-terminal amidation.

Literature Information

  • ·Literature 1

    • Title

    • De novo generation of short antimicrobial peptides with simple amino acid composition.

    • Reference

    • Regul Pept. 2011 Jan 17;166(1-3):36-41.

    • Author

    • Lee SH, Kim SJ, Lee YS, Song MD, Kim IH, Won HS.