General Information

    • DRAMP ID

    • DRAMP04186

    • Peptide Name

    • L5K5W1 (L5K5Wn model peptide)

    • Source

    • Synthetic construct (De novo design)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • WLKKLLKKLLK

    • Sequence Length

    • 11

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacteria: Bacillus subtilis ATCC 6633 (MIC=2 µg/mL), Staphylococcus aureus ATCC 6538p (MIC=2 µg/mL), Staphylococcus epidermis ATCC 12228 (MIC=2 µg/mL), Micrococcus luteus ATCC 10240 (MIC=4 µg/mL), MRSA-TK784 (MIC=8 µg/mL).
      • Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=4 µg/mL), Shigella dysenteriae ATCC 9752 (MIC=2 µg/mL), Salmonella typhimurium ATCC 14028 (MIC=2 µg/mL), Klebsiella pneumoniae ATCC 10031 (MIC=2 µg/mL), Pseudomonas aeruginosa ATCC 27853 (MIC=8 µg/mL).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04186 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP04186.

Physicochemical Information

    • Formula

    • C71H127N17O12

    • Absent Amino Acids

    • ACDEFGHIMNPQRSTVY

    • Common Amino Acids

    • KL

    • Mass

    • 1410.9

    • PI

    • 10.6

    • Basic Residues

    • 5

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +5

    • Boman Index

    • -0.82

    • Hydrophobicity

    • -0.127

    • Aliphatic Index

    • 177.27

    • Half Life

      • Mammalian:2.8 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 550

    • Polar Residues

    • 0

DRAMP04186

Comments Information

    • Function

    • Has antibacterial activity against the Gram-positive, Gram-negative bacteria and a multi-drug resistant strain.

    • Chemical modification

    • C-terminal amidation.

Literature Information

  • ·Literature 1

    • Title

    • Structural characterization of de novo designed L5K5W model peptide isomers with potent antimicrobial and varied hemolytic activities.

    • Reference

    • Molecules. 2013 Jan 11;18(1):859-876.

    • Author

    • Kim SJ, Kim JS, Lee YS, Sim DW, Lee SH, Bahk YY, Lee KH, Kim EH, Park SJ, Lee BJ, Won HS.