General Information
-
DRAMP ID
- DRAMP04198
-
Peptide Name
- PenArg
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- RQIRIWFQNRRMRWRR
-
Sequence Length
- 16
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
-
Target Organism
-
- [Ref.23085001] Gram-positive bacteria : Staphylococcus aureus(ATCC 33591)(MIC=16 μM);
- Gram-negative bacteria : Escherichia coli(ATCC 25922)(MIC=8 μM)
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Hemolytic Activity
-
- [Ref.23085001] HC50>128 μM against human red blood cells
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Alpha helix
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- Please click DRAMP04198_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C104H168N42O20S
Absent Amino Acids
- ACDEGHKLPSTVY
Common Amino Acids
- R
Mass
- 2358.81
PI
- 12.78
Basic Residues
- 7
Acidic Residues
- 0
Hydrophobic Residues
- 5
Net Charge
- +7
-
Boman Index
- -102.33
Hydrophobicity
- -1.881
Aliphatic Index
- 48.75
Half Life
-
- Mammalian:1 hour
- Yeast:2 min
- E.coli:2 min
Extinction Coefficient Cystines
- 11000
Absorbance 280nm
- 733.33
Polar Residues
- 1
DRAMP04198
Comments Information
Function
- Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria
Literature Information
- ·Literature 1
-
Title
- Antimicrobial and cell-penetrating properties of penetratin analogs: Effect of sequence and secondary structure.
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Pubmed ID
- 23085001
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Reference
- Biochim Biophys Acta. 2013 Feb;1828(2):223-232. doi: 10.1016/j.bbamem.2012.10.010.
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Author
- Bahnsen JS, Franzyk H, Sandberg-Schaal A, Nielsen HM.