General Information

    • DRAMP ID

    • DRAMP04213

    • Peptide Name

    • BP100

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • KKLFKKILKYL

    • Sequence Length

    • 11

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.29750913] Gram-negative bacteria:Escherichia coli(ATCC 25922)(MIC=2 μM);
      • Gram-positive bacteria:Staphylococcus aureus (ATCC 25923)(MIC=2μM);Bacillus subtilis(PY79)(MIC=2μM)

    • Hemolytic Activity

      • [Ref.29750913] 10% hemolysis at 64μM against human red blood cell

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Alpha helix

    • Structure Description

    • The peptide adopted with positively charged residues on one face and the hydrophobic residues on the opposite face of the helix

    • Helical Wheel Diagram

    • DRAMP04213 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP04213.

Physicochemical Information

    • Formula

    • C72H124N16O13

    • Absent Amino Acids

    • ACDEGHMNPQRSTVW

    • Common Amino Acids

    • K

    • Mass

    • 1421.88

    • PI

    • 10.3

    • Basic Residues

    • 5

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 5

    • Net Charge

    • +5

    • Boman Index

    • -5.23

    • Hydrophobicity

    • -0.191

    • Aliphatic Index

    • 141.82

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 149

    • Polar Residues

    • 1

DRAMP04213

Comments Information

    • Function

    • Antibacterial activity against the Gram-positive and Gram-negative bacteria. Has hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Synthesis, biophysical and functional studies of two BP100 analogues modified by a hydrophobic chain and a cyclic peptide.

    • Reference

    • Biochim Biophys Acta. 2018 Aug;1860(8):1502-1516.

    • Author

    • Carretero GPB, Saraiva GKV, Cauz ACG, Rodrigues MA, Kiyota S, Riske KA, Dos Santos AA, Pinatto-Botelho MF, Bemquerer MP, Gueiros-Filho FJ, Chaimovich H, Schreier S, Cuccovia IM.