General Information

    • DRAMP ID

    • DRAMP04234

    • Peptide Name

    • D51 (Rational design peptide)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FLFRVASKVFPALIGKFKKK

    • Sequence Length

    • 20

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus (MIC=16 µg/ml), Bacillus anthracis (MIC=16 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04234 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP04234.

Physicochemical Information

    • Formula

    • C116H186N28O22

    • Absent Amino Acids

    • CDEHMNQTWY

    • Common Amino Acids

    • K

    • Mass

    • 2324.93

    • PI

    • 11.39

    • Basic Residues

    • 6

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +6

    • Boman Index

    • -6.75

    • Hydrophobicity

    • 0.425

    • Aliphatic Index

    • 97.5

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 2

DRAMP04234

DRAMP04234 chydropathy plot

Comments Information

    • Function

    • Has strong bacteriostatic activity against several species of bacteria, including Staphylococcus aureus and Bacillus anthracis.

Literature Information

  • ·Literature 1

    • Title

    • A linguistic model for the rational design of antimicrobial peptides.

    • Reference

    • Nature. 2006 Oct 19;443(7113):867-869.

    • Author

    • Loose C, Jensen K, Rigoutsos I, Stephanopoulos G.