• DRAMP ID

    • DRAMP04235
    • Peptide Name

    • D22 (Rational design peptide)
    • Source

    • Synthetic construct
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • LGALFRVASKVFPAVISMVK
    • Sequence Length

    • 20
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Synthetic
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+
    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus (MIC=64 µg/ml), Bacillus anthracis (MIC=64 µg/ml).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP04235 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP04235.
    • Formula

    • C101H169N25O23S
    • Absent Amino Acids

    • CDEHNQTWY
    • Common Amino Acids

    • V
    • Mass

    • 2133.67
    • PI

    • 11.17
    • Basic Residues

    • 3
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 12
    • Net Charge

    • +3
    • Boman Index

    • 12.78
    • Hydrophobicity

    • 1.295
    • Aliphatic Index

    • 131.5
    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 3

DRAMP04235

DRAMP04235 chydropathy plot
    • Function

    • Has strong bacteriostatic activity against several species of bacteria, including Staphylococcus aureus and Bacillus anthracis.
  • ·Literature 1
    • Title

    • A linguistic model for the rational design of antimicrobial peptides.
    • Reference

    • Nature. 2006 Oct 19;443(7113):867-869.
    • Author

    • Loose C, Jensen K, Rigoutsos I, Stephanopoulos G.