General Information

    • DRAMP ID

    • DRAMP04237

    • Peptide Name

    • Antibacterial peptide A4

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GLFDIVKKLVSDF

    • Sequence Length

    • 13

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • Gram-negative bacterium: Escherichia coli (MIC=100 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Alpha helix (1 helices; 8 residues)

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04237 helical wheel diagram

    • PDB ID

    • 1VM4 resolved by NMR.
  • 1VM4-> 

    • Predicted Structure

Physicochemical Information

    • Formula

    • C71H113N15O19

    • Absent Amino Acids

    • ACEHMNPQRTWY

    • Common Amino Acids

    • DFKLV

    • Mass

    • 1480.77

    • PI

    • 5.96

    • Basic Residues

    • 2

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 7

    • Net Charge

    • 0

    • Boman Index

    • -2.2

    • Hydrophobicity

    • 0.777

    • Aliphatic Index

    • 134.62

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 2

DRAMP04237

Comments Information

    • Function

    • Has antibacterial activity against the Gram-negative bacterium E. coli.

Literature Information

  • ·Literature 1

    • Title

    • Correlation of three-dimensional structures with the antibacterial activity of a group of peptides designed based on a nontoxic bacterial membrane anchor.

    • Reference

    • J Biol Chem. 2005 Feb 18;280(7):5803-5811.

    • Author

    • Wang G, Li Y, Li X.