General Information

    • DRAMP ID

    • DRAMP04238

    • Peptide Name

    • PL-101

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FFHLHFHY

    • Sequence Length

    • 8

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.12569105] Gram-negative bacterium: Escherichia coli (MEC=7 μg/ml), Pseudomonas aeruginosa (MEC=10 μg/ml).;
      • Gram-positive bacteria: Staphylococcus aureus (MEC=3 μg/ml), MRSA (MEC=4 μg/ml) at PH 6.5.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04238 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP04238.

Physicochemical Information

    • Formula

    • C60H70N14O10

    • Absent Amino Acids

    • ACDEGIKMNPQRSTVW

    • Common Amino Acids

    • FH

    • Mass

    • 1147.3

    • PI

    • 7.02

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +3

    • Boman Index

    • -0.26

    • Hydrophobicity

    • 0.163

    • Aliphatic Index

    • 48.75

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 212.86

    • Polar Residues

    • 1

DRAMP04238

Comments Information

    • Function

    • Antibacterial activity against Gram-negative bacteria and Gram-positive bacteria.

Literature Information

  • ·Literature 1

    • Title

    • Plicatamide, an antimicrobial octapeptide from Styela plicata hemocytes.

    • Reference

    • J Biol Chem. 2003 Apr 11;278(15):13546-53.

    • Author

    • Tincu JA, Menzel LP, Azimov R, Sands J, Hong T, Waring AJ, Taylor SW, Lehrer RI.