General Information
-
DRAMP ID
- DRAMP04244
-
Peptide Name
- Synthetic 5
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- RLKLLLRLK
-
Sequence Length
- 9
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- Gram-positive bacteria: Staphylococcus aureus (MIC=2 µg/ml), S. aureus (MRSA) (MIC>35 µg/ml).
- Gram-negative bacterium: Escherichia coli (MIC=20 µg/ml).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP04244.
Physicochemical Information
-
Formula
- C54H105N17O10
Absent Amino Acids
- ACDEFGHIMNPQSTVWY
Common Amino Acids
- L
Mass
- 1152.54
PI
- 12.02
Basic Residues
- 4
Acidic Residues
- 0
Hydrophobic Residues
- 5
Net Charge
- +4
-
Boman Index
- -16.34
Hydrophobicity
- 0.244
Aliphatic Index
- 216.67
Half Life
-
- Mammalian:1 hour
- Yeast:2 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 0
DRAMP04244
Comments Information
Function
- Has antibacterial activity against the Gram-positive and Gram-negative bacteria.
Literature Information
- ·Literature 1
-
Title
- Novel synthetic antimicrobial peptides effective against methicillin-resistant Staphylococcus aureus.
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Pubmed ID
- 8093007
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Reference
- Biochem J. 1994 Sep 1;302 ( Pt 2):535-538.
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Author
- Alvarez-Bravo J, Kurata S, Natori S.