General Information

    • DRAMP ID

    • DRAMP04250

    • Peptide Name

    • (KLAGLAK)3-NH2

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • KLAGLAKKLAGLAKKLAGLAK

    • Sequence Length

    • 21

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04250 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP04250.

Physicochemical Information

    • Formula

    • C96H179N27O22

    • Absent Amino Acids

    • CDEFHIMNPQRSTVWY

    • Common Amino Acids

    • AKL

    • Mass

    • 2063.64

    • PI

    • 10.7

    • Basic Residues

    • 6

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +6

    • Boman Index

    • 9.9

    • Hydrophobicity

    • 0.429

    • Aliphatic Index

    • 140

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP04250

DRAMP04250 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • A Novel Linear Amphipathic b-Sheet Cationic Antimicrobial Peptide with Enhanced Selectivity for Bacterial Lipids.

    • Reference

    • J Biol Chem. 2001 Jul 27;276(30):27899-27906.

    • Author

    • Blazyk J, Wiegand R, Klein J, Hammer J, Epand RM, Epand RF, Maloy WL, Kari UP.