General Information

    • DRAMP ID

    • DRAMP04274

    • Peptide Name

    • CP206

    • Source

    • Synthetic construct

    • Family

    • Derived from the peptide CP26, CP29, CEME and CEMA

    • Gene

    • Not found

    • Sequence

    • KKWWKFIKKAVNSGTTGLQTLAS

    • Sequence Length

    • 23

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • Gram-negative bacteria: Escherichia coli (MIC=8 μg/ml), Pseudomonas aeruginosa H744 (MIC=16 μg/ml), Pseudomonas aeruginosa H374 (MIC=8 μg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Lipopolysaccharide (LPS)-binding

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04274 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C121H194N32O31

    • Absent Amino Acids

    • CDEHMPRY

    • Common Amino Acids

    • K

    • Mass

    • 2593.07

    • PI

    • 10.6

    • Basic Residues

    • 5

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +5

    • Boman Index

    • -22.5

    • Hydrophobicity

    • -0.439

    • Aliphatic Index

    • 72.17

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 11000

    • Absorbance 280nm

    • 500

    • Polar Residues

    • 8

DRAMP04274

DRAMP04274 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against Gram-negative bacteria.

Literature Information

  • ·Literature 1

    • Title

    • Biological properties of structurally related alpha-helical cationic antimicrobial peptides.

    • Reference

    • Infect Immun. 1999 Apr;67(4):2005-2009.

    • Author

    • Scott MG, Yan H, Hancock RE.