General Information

    • DRAMP ID

    • DRAMP04277

    • Peptide Name

    • CP209

    • Source

    • Synthetic construct

    • Family

    • Derived from the peptide CP26, CP29, CEME and CEMA

    • Gene

    • Not found

    • Sequence

    • WKVFKSFIKKASSFAQSVLD

    • Sequence Length

    • 20

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • Gram-negative bacteria: Escherichia coli (MIC=11 μg/ml), Pseudomonas aeruginosa Z61 (MIC=64 μg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Lipopolysaccharide (LPS)-binding

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04277 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C111H170N26O28

    • Absent Amino Acids

    • CEGHMNPRTY

    • Common Amino Acids

    • KS

    • Mass

    • 2316.73

    • PI

    • 10

    • Basic Residues

    • 4

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +3

    • Boman Index

    • -17.25

    • Hydrophobicity

    • 0.1

    • Aliphatic Index

    • 78

    • Half Life

      • Mammalian:2.8 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 289.47

    • Polar Residues

    • 4

DRAMP04277

DRAMP04277 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against Gram-negative bacteria.

Literature Information

  • ·Literature 1

    • Title

    • Biological properties of structurally related alpha-helical cationic antimicrobial peptides.

    • Reference

    • Infect Immun. 1999 Apr;67(4):2005-2009.

    • Author

    • Scott MG, Yan H, Hancock RE.