General Information

    • DRAMP ID

    • DRAMP04283

    • Peptide Name

    • CM4

    • Source

    • Synthetic construct

    • Family

    • Derived from the peptide CP26, CP29, CEME and CEMA

    • Gene

    • Not found

    • Sequence

    • KWKLFKKIGIGAVLKVLTTGLPALKLTLK

    • Sequence Length

    • 29

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • Gram-negative bacteria: Escherichia coli (MIC=3 μg/ml), Salmonella typhimurium (MIC=3 μg/ml), Pseudomonas aeruginosa K799 (MIC=4 μg/ml), Pseudomonas aeruginosa Z61 (MIC=3 μg/ml), Pseudomonas aeruginosa H744 (MIC=4 μg/ml), Pseudomonas aeruginosa H547 (MIC=4 μg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Lipopolysaccharide (LPS)-binding

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04283 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C155H269N37O33

    • Absent Amino Acids

    • CDEHMNQRSY

    • Common Amino Acids

    • KL

    • Mass

    • 3179.07

    • PI

    • 10.78

    • Basic Residues

    • 7

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 15

    • Net Charge

    • +7

    • Boman Index

    • 17.55

    • Hydrophobicity

    • 0.597

    • Aliphatic Index

    • 147.93

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 196.43

    • Polar Residues

    • 6

DRAMP04283

DRAMP04283 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against Gram-negative bacteria.

Literature Information

  • ·Literature 1

    • Title

    • Biological properties of structurally related alpha-helical cationic antimicrobial peptides.

    • Reference

    • Infect Immun. 1999 Apr;67(4):2005-2009.

    • Author

    • Scott MG, Yan H, Hancock RE.