General Information

    • DRAMP ID

    • DRAMP04359

    • Peptide Name

    • PDD-A-1 (PDD-A analog)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • INWKKIFQKVKNLV

    • Sequence Length

    • 14

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.18375018]Gram-negative bacterium: Escherichia coli (MIC=8 µM);
      • Gram-positive bacterium: Bacillus subtilis (MIC=45 µM).

    • Hemolytic Activity

      • [Ref.18375018]IC50 = 100 μM against rat red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP04359 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C85H140N22O18

    • Absent Amino Acids

    • ACDEGHMPRSTY

    • Common Amino Acids

    • K

    • Mass

    • 1758.18

    • PI

    • 10.48

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +4

    • Boman Index

    • -12.87

    • Hydrophobicity

    • -0.214

    • Aliphatic Index

    • 125

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 423.08

    • Polar Residues

    • 2

DRAMP04359

Comments Information

    • Function

    • Has antimicrobial activity against the Gram-positive bacterium B. subtilis and Gram-negative bacterium E. coli. PDD-A also shows hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs.

    • Reference

    • Peptides. 2008 Jun;29(6):992-1003.

    • Author

    • Cerovský V, Slaninová J, Fucík V, Hulacová H, Borovicková L, Jezek R, Bednárová L.